Comparing Testosterone Cypionate vs Enanthate

Testosterone Injections: Uses & Side Effects

Both Testosterone Enanthate and Cypionate are delivered through intramuscular injection, most commonly in the gluteal muscles or vastus lateralis (thigh). Testosterone is a vital hormone that plays a crucial role in the development and maintenance of male characteristics, although it is present in both men and women. In men, testosterone is produced primarily in the testes, while in women, it is produced in smaller amounts in the ovaries and adrenal glands.

Some of these side effects may vary based on the testosterone product you are using and why you are using it. Testosterone should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can high testosterone cause inflammation (bewellprimarycare.com) be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it.

Morgentaler and colleagues conducted a retrospective cohort study of data from the Veradigm database, which consists of electronic health record data from ambulatory facilities in the U.S. Men aged 18 years and older who initiated testosterone undecanoate or testosterone cypionate injections from 2014 to 2018 were included. Data were collected in 6-month increments through July 2019. Maintenance of treatment was defined as a gap no more than twice the recommended dosing interval of 20 weeks for testosterone undecanoate or 4 weeks of testosterone cypionate between prescriptions. Treatment adherence was assessed from the date of the first injection until discontinuation, a prescription switch or the end date of the originally prescribed testosterone therapy. Nonadherence in the testosterone cypionate group was defined as a gap of more than 21 days between the end of one prescription and the start of the next. The goal of testosterone replacement therapy (TRT) is to return serum testosterone levels to within physiologic range and improve symptoms in hypogonadal men.

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases. During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH). It is of note that almost none of the quoted studies had been specifically designed to assess the time-course of effects. Some studies measure effects of testosterone only after 3 months (31), and, particularly, effects on libido and erections have occurred well before this time span (14, 68). This is a systematic analysis of the time-course of the spectrum of biological effects of testosterone on the various target systems.

Call your health care provider right away if you have any of the following symptoms of liver damage. Stop using testosterone and get emergency help if you have any of the following signs of blood clots. If you measure your blood pressure and the top number (systolic) is 180 or higher or the bottom number (diastolic) is 120 or higher, get medical attention right away. Increases in blood pressure may not be noticeable, but look out for and tell your health care provider right away if you have any of the following symptoms of severely high blood pressure. Testosterone may increase your blood pressure or make it worse if you have a history of high blood pressure.

If you feel that the medicine is not working as well, do not use more than your prescribed dose. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. A doctor or other trained health professional will give you this medicine in a hospital.

This formulation required a high capsule burden due to low bioavailability along with gastrointestinal and liver adverse effects (12,13). Currently, oral testosterone preparations are not options for TRT in the USA due to these adverse effects. Lab and/or medical tests (such as blood testosterone levels, red blood cell counts, liver function, blood cholesterol levels, PSA test) should be done while you are using this medication. Nausea, vomiting, headache, skin color changes, increased/decreased sexual interest, oily skin, hair loss, and acne may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

You may report side effects to FDA at FDA-1088 or at /medwatch. Some brands of this medication have a Medication Guide provided by your pharmacist. If one is available, read the Medication Guide before your start taking this medication and each time you get a refill.